| 摘要 |
The present invention relates generally to chemical agents useful in the treatment and prophylaxis of protein kinase C (PKC) related conditions in mammals, including humans and primates, non-mammalian animals and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtainable from a member of the Euphorbiace ae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogues or chemically synthetic forms of the agent s for use in the treatment or prophylaxis of PKC-related conditions in mammalian, animal and avian subjects. The subject chemical agents are also useful for modulating expression of genetic sequences including promotion an d other regulatory sequences. The present invention further contemplates a method for the prophylaxis and/or treatment in mammalian, animal or avian subjects with PKC-related conditions by the topical or systemic administrati on of a macrocyclic diterpene obtainable from a member of the Euphorbiaceae family of plants or their botanical or horticultural derivatives or a derivative, chemical analogue or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically and/or genetically active agent or in the form of a chemical fraction, sub-fraction , preparation or extract of the plant. |
