METHOD TO INDUCE THE TH1 IMMUNE RESPONSE

摘要

The present invention discloses a method to induce the CD4+ Th1 immune response, combined with a repression of the Th2 mediated activities. The method comprises administering an IgG isotype antibody, which is not an IgG1 isotype antibody. The antibody is an IgG2a and/or IgG2b isotype anti-allergen antibody. The shift from a Th2 response towards a mixed Th1/Th2 response is useful in the treatment of diseases, such as asthma. Since the disclosed method corrects the immuno-pathological cause of the disease, the polarized Th2 response against allergen, a sustained cure from asthma may be achieved.