| 摘要 |
Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. The present invention further provides methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures.
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| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;BURKE, TERRENCE, R., JR.;BOTTARO, DONALD, P.;ATABEY, SAFIYE, N.;SORIANO, JESUS, V.;BRECKENRIDGE, DIANE, E.;YAO, ZHU-JUN;GAO, YANG |
发明人 |
BOTTARO, DONALD, P.;ATABEY, SAFIYE, N.;SORIANO, JESUS, V.;BRECKENRIDGE, DIANE, E.;YAO, ZHU-JUN;GAO, YANG |
