TWO-HYBRID ASSAY THAT DETECTS HIV-1 REVERSE TRANSCRIPTASE DIMERIZATION

摘要

This invention provides methods of determining wheter a compound inhibits HI V- 1 reverse transcriptase. This invention provides methods of determining whether a compound inhibits formation of a complex between a p66 and p51 subunit polypeptides of HIV-1 reverse transcriptase. This invention provides a method of determining whether a compund enhances formation of a complex between a p66 and p51 subunit polypeptides of HIV-1 reverse transcriptase. This invention provides methods of determining whether a compound inhibits formation of a complex between two p66 subunit polypeptides of HIV-1 reverse transcriptase. This invention provides methods of determining whether a compound enhances formation of a complex between two p66 subunit polypeptide s of HIV-1 reverse transcriptase.