HETEROCYCLE DERIVATIVES AND METHODS OF USE

摘要

The present invention provides for the inhibition of adenylate cyclase in vitro and in vivo, for the treatment of intestinal fluid loss, for the inhibition of smooth muscle contraction, including the contraction of the uterus during, for instance, premature labor; for the treatment of whooping cough, (linked e.g. to Bordetella pertussis), and to provide for the treatment of anthrax. Useful compounds include imidazole and compounds selected from the group consisting of colecoxib, rofecoxib, 5-(4-chlorophenyl)- 1-(4-methoxyphenyl)- 3-(trifluoromethyl)- 1H-pyrazole, DuP-697 (5-bromo- 2-(4-fluorophenyl)- 3-[4- (methylsulfonyl)phenyl]-thiophene), 1-[(2R,3R)- 3-[(2Z)- 6-carboxy-2-hexenyl]-2- (1E)-1-octenyl- 4-oxocyclopentyl]-1- imidazole, 1-[(2R,3R)- 3-[(2Z)-6- carboxy-2-hexenyl]-2- (1E)-1-octenyl-4- oxocyclopentyl]-L-Histidine, metronidazole, indomethacine.