New 1-(dimercaptoalkyl)-quinazoline-2,4(1H,3H)-diones, are stable matrix metalloproteinase inhibitors useful e.g. for treating rheumatism, tumor metastasis or sunburn

摘要

The aim of the invention is the discovery and investigation of novel chemical entities of a non-proteinogenic structure which have a matrix-metalloproteinase(MMP)-inhibiting effect. Said aim is achieved by means of the synthesis of dimercaptoalkyl-substituted quinazolin-2,4(1H,3H)-diones. Compounds of the above substance class display an unexpectedly clear and hence pharmacologically interesting MMP-inhibiting effect.