发明名称 |
NITRIC OXIDE-MODIFIED LINEAR POLY(ETHYLENIMINE) FIBERS AND USES THEREFOR |
摘要 |
A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide (NO) in a controlled manner to tissues and organs to aid the healing process and to prevent injury to tissues at risk of injury. Electrospun nanofibers of linear poly(ethylenimine)diazeniumdiolate deliver therapeutic levels of NO to the tissues surrounding a medical device while minimizing the alteration of the properties of the device. A nanofiber coating, because of the small size and large surface area per unit mass of the nanofibers, provides a much larger surface area per unit mass while minimizing changes in other properties of the device. |
申请公布号 |
WO0126702(A3) |
申请公布日期 |
2001.12.13 |
申请号 |
WO2000US27769 |
申请日期 |
2000.10.06 |
申请人 |
THE UNIVERSITY OF AKRON |
发明人 |
SMITH, DANIEL;RENEKER, DARRELL |
分类号 |
A61L15/26;A61L15/44;A61L17/14;A61L27/34;A61L27/54;A61L29/08;A61L29/16;A61L31/10;A61L31/16;(IPC1-7):A61L27/54 |
主分类号 |
A61L15/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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