| 发明名称 |
MUTATED FURIN POLYPEPTIDES HAVING IMPROVED CHARACTERISTICS |
| 摘要 |
<p num="1"><br/><br/><br/>The present invention comprises a furin polypeptide having a modified amino <br/>acid sequence between the middle, homo-B-domain and the transmembrane domain <br/>compared to wild-type furin which retains proteolytic activity but is secreted <br/>at lower levels in cell culture compared to wild-type furin. Additionally, the <br/>invention includes nucleic acid molecules encoding such furin polypeptides, <br/>vectors and host cells comprising said nucleic acid molecules, compositions <br/>comprising said furin polypeptide and methods for producing such compositions.<br/>
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| 申请公布号 |
CA2411694(A1) |
申请公布日期 |
2001.12.13 |
| 申请号 |
CA20012411694 |
申请日期 |
2001.05.25 |
| 申请人 |
BAXTER AKTIENGESELLSCHAFT |
发明人 |
SCHLOKAT, UWE;PLAIMAUER, BARBARA |
| 分类号 |
C12N15/09;A61K38/00;A61K48/00;C07K14/755;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/64;C12N15/57;C12N15/84;(IPC1-7):C12N9/64;A61K38/48 |
主分类号 |
C12N15/09 |
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