| 摘要 |
PROBLEM TO BE SOLVED: To provide a method of producing Schiff's base always in high yield from a ketone and an amine with no effect from the kinds of the starting substances to be used and from the reaction conditions. SOLUTION: In the presence of an organic solvent that can form the azeotropic mixture with water, for example, benzene or toluene, a ketone, for example, propiophenone is subjected to the dehydrative condensation with an amine, for example, ethoxyethylamine compound to form the corresponding Schiff' base. In this case, water formed as a by-product is azeotropically distilled off together with the organic solvent from the reaction system and condensed into the liquid phase. Then, the resultant condensate is brought into contact with a salt, for example, sodium chloride or a base, for example, sodium hydroxide to be separated into two phases, the aqueous layer and the organic layer and the dehydrative condensation reaction is continued, as the organic layer separated is allowed to turn back into the reaction system.
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