SEARCHING SYSTEM FOR INSULIN-RESISTANT AMELIORANT WITHOUT POSSIBILITY OF EXACERBATING DIABETIC RETINOPATHY AND WITHOUT EDEMA INDUCING ACTION

摘要

PROBLEM TO BE SOLVED: To provide both a method for screening an insulin-resistant ameliorant without the possibility of exacerbating diabetic retinopathy and without edema inducing actions and the insulin-resistant ameliorant obtained by the method for screening. SOLUTION: This insulin-resistant ameliorant without the possibility of exacerbating the diabetic retinopathy and without the edema inducing actions is obtained by transducing a recombinant gene prepared by binding a human vascular endothelial growth factor gene containing a promoter region to a reporter gene into a mammalian cell and detecting the expression of the human vascular endothelial growth factor gene by the expression of the reporter gene of the cell.