发明名称 |
Inhibitors of prenyl-protein transferase |
摘要 |
The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit a prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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申请公布号 |
US6329376(B1) |
申请公布日期 |
2001.12.11 |
申请号 |
US19990426533 |
申请日期 |
1999.10.26 |
申请人 |
MERCK & CO., INC. |
发明人 |
BERGMAN JEFFREY M. |
分类号 |
C07D498/14;C07D498/22;(IPC1-7):A61K31/495;C07D267/00;C07D281/00;C07D291/00 |
主分类号 |
C07D498/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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