发明名称 |
PROCEDE UTILE POUR TRANSFORMER LA FONCTION CARBONYLE EN POSITION 4 DU MOTIF CLADINOSE D'UN AZA MACROLIDE EN UN DERIVE AMINE |
摘要 |
The invention concerns a method for preparing a compound of general formula (I) by reducing amination of a corresponding (4'')-carbonyl derivative. The invention is characterised in that it consists in: bringing said (4'')-carbonyl derivative into the presence of at least a nitrogenous reagent and a Lewis acid in conditions suited for transforming the cabonyl 4'' function; reducing the resulting mixture using a reducing agent; and optionally deprotecting the hydroxide function in position 2', to lead to the expected compound of general formula (I).
|
申请公布号 |
FR2809728(A1) |
申请公布日期 |
2001.12.07 |
申请号 |
FR20000006942 |
申请日期 |
2000.05.30 |
申请人 |
MERIAL |
发明人 |
DHAINAUT JILDAZ;LEON PATRICK;LHERMITTE FREDERIC;ODDON GILLES |
分类号 |
A61P31/04;C07B61/00;C07H17/00;C07H17/08;(IPC1-7):C07D269/00 |
主分类号 |
A61P31/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|