The present invention relates to the modification of the CC chemokine receptor 3 to stabilise or enhance surface expression, for example, to reduce internalization and/or kinase-mediated phosphorylation. The invention also relates to assays for CCR3 receptor activity in which internalization and/or kinase mediated phosphorylation of the receptor is reduced.
申请公布号
WO0192520(A1)
申请公布日期
2001.12.06
申请号
WO2001EP06195
申请日期
2001.05.31
申请人
GLAXO GROUP LIMITED;BARNES, ASHLEY, ANTONY;FRASER, NEIL, JAMES;O'SHAUGHNESSY, CELESTINE, THERESA;WISE, ALAN
发明人
BARNES, ASHLEY, ANTONY;FRASER, NEIL, JAMES;O'SHAUGHNESSY, CELESTINE, THERESA;WISE, ALAN
