Measurement comprising electronic chemo- and bio-sensors, for determining expected and actual values when calibration substance is applied to sensor

摘要

Measurement using electronic chemo- and bio-sensors comprising a calibration substance is applied to the sensor, measuring the resulting electrical value, determinign the difference between measured and expected values to calculating a correction value and using this for compensation, during measurement of analytes, is new. A calibration substance is applied to the sensor, measuring the resulting electrical value. The difference between measured and expected values is determined, to calculate a correction value. This is used for compensation, during measurement of analytes. An Independent claim is included for corresponding apparatus. This includes a calibration system to determine and/or compensate difference in an electrical value. A controller (23) is provided for control and read-out of the sensor. A process controller carries out measurements with it. Preferred Features: The difference and/or correction value is stored in memory (32, 32a). In addition an analyte is applied to the sensor for measurement and a compensated value is determined for the analyte. Two or more analytes can be measured using the apparatus (1). Sensors are provided for different substances. Many sensors are arranged in at least one dimension. The analyte has an extent covering at least part of the arrangement. At least one value of the analytes is measured by the sensors. The values are spatially resolved over the dimension(s). The electrical value is a voltage, resistance, current, capacity and/or an inductance, or a combination of these. At least one sensor is a field effect transistor (17). The electrical value is the difference between measured- and expected potentials at a terminal of the FET (17). The electrical value is a capacity, inductance or impedance between two electrodes of the sensor, following application of the substance. The correction value is applied to analyte measurements by computer. Alternatively, the correction value is used to influence sensors, hence eliminating a calibration difference during analyte measurements.