发明名称 |
COMPOUNDS WITH A SULPHONAMIDE GROUP AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
摘要 |
The invention relates to compounds which, acting as a prodrug and/or support, enable an active agent to be taken up by the erythrocytes and/or an active agent to bind to the erythrocytes. The uptake of these compounds by and/or the binding thereof to the erythrocytes is made possible by a group of formula -SO2NR<1>R<2>, wherein R<1> and R<2>, independently of each other, mean a hydrogen atom, an acyl group, an alkyl group, a cycloalkyl group, an aryl group, a cyano group or a hydroxy group. The inventive prodrugs enable active agents such as endogenic substances, natural substances and synthetic substances with therapeutically useful properties which have a high "first path" effect, to be administered orally effectively or significantly improve the oral activity thereof. |
申请公布号 |
WO0191797(A2) |
申请公布日期 |
2001.12.06 |
申请号 |
WO2001EP05169 |
申请日期 |
2001.05.08 |
申请人 |
JENAPHARM GMBH & CO. KG;ELGER, WALTER;HILLISCH, ALEXANDER;HEDDEN, ANNEMARIE;SCHWARZ, SIGFRID;SCHOELLKOPF, KLAUS |
发明人 |
ELGER, WALTER;HILLISCH, ALEXANDER;HEDDEN, ANNEMARIE;SCHWARZ, SIGFRID;SCHOELLKOPF, KLAUS |
分类号 |
A61K47/48;A61P33/06;A61P43/00;C07J41/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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