INHIBITING RETROVIRAL INTEGRATION BY TARGETING THE ATM PATHWAY

摘要

Ataxia telangiectasia mutated (ATM)-dependent DNA damage signalling mechanisims are involved in retroviral and retrotransposon integration. Screening methods for inhibitors of retroviral and retrotranspons activity comprise inhibiting the ATM-dependent DNA damage signalling pathway, e.g. by disrupting interaction between components of the pathway. Inhibitors are useful as anti-retroviral agents, e.g. in inhibition of HIV.