发明名称 |
METHOD FOR OPTICALLY RESOLVING A RACEMIC ALPHA-SUBSTITUTED HETEROCYCLIC CARBOXYLIC ACID USING ENZYME |
摘要 |
Disclosed is a method for optically resolving a racemic alpha-substituted heterocyclic carboxylic acid (alpha-HCCA) by taking advantage of enantioselectivity of enzymes. alpha-HCCA is reacted with alcohol to give a racemic alpha-HCCA ester, which is then reacted with an enzyme with enantioselectivity, whereby either R-form or S-form of the racemate is hydrolyzed. Extraction with an organic solvent can obtain enantiomers of the alpha-HCCA ester. The extracted enantiomeric alpha-HCCA ester is converted to enantiomeric alpha-HCCA by catalytic hydrogenation in an organic solution or by enzymatic hydrolysis in an aqueous solution. Thus, a racemic mixture of alpha-HCCA can be optically resolved with high optical purity at high yields as well as at low cost. |
申请公布号 |
WO0192553(A1) |
申请公布日期 |
2001.12.06 |
申请号 |
WO2001KR00884 |
申请日期 |
2001.05.25 |
申请人 |
SK CORPORATION |
发明人 |
UHM, KI-NAM;LIM, SANG-CHUL;LIM, JONG-HO |
分类号 |
C12P17/04;C12P41/00 |
主分类号 |
C12P17/04 |
代理机构 |
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代理人 |
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