TUMOR ACTIVATED PRODRUG COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
摘要
The invention is directed to novel prodrug compounds, compositions comprising the prodrug compounds, methods of making the prodrug compounds and methods of using the prodrug compounds. The prodrug compounds comprise a biologically active entity linked to a masking moiety <i>via</i> a linking moiety. The prodrug compounds are selectively activated at or near target cells and display lower toxicity and possibly a longer <i>in vivo</i> or serum half-life than the corresponding naked biologically active entity.
申请公布号
WO0191798(A2)
申请公布日期
2001.12.06
申请号
WO2001EP06106
申请日期
2001.05.29
申请人
UNIVERSITE CATHOLIQUE DE LOUVAIN;TROUET, ANDRE;DUBOIS, VINCENT;ORONSKY, ARNOLD