| 摘要 |
<p>A method of evaluating the efficacy of molecules against a target population including a strain resistant to a first toxin includes determining a susceptible strain in the target population and selecting for the resistant strain in the target population. The susceptible strain being susceptible to the first toxin and the resistant strain being resistant to the first toxin. The method further includes evaluating the efficacy of the resistant strain with a plurality of molecules to determine a second toxin that is more toxic to the resistant strain than to the susceptible strain, evaluating the efficacy of a heterozygous strain of the target population with separate applications of the first toxin and the second toxin, and assigning a priority rating to the second toxin if the separate applications of the first toxin and the second toxin are at least as toxic to the heterozygous strain as to the susceptible strain.</p> |
