DIAGNOSIS AND TREATMENT OF HERPES INFECTIONS

摘要

Methods and compositions for treating or preventing virus infections by interfering with the activity or function of Ras, the Ras pathway, the ERK pathway, MEK1/2, PKR or eIF-2 alpha , includes the use of agents which inhibit Ras or otherwise modulate anti-PKR activity. Also, a method of diagnosing such virus infections includes the use of cell lines that have an activated Ras pathway, including cell lines which have been transformed with a gene that activates the Ras pathway. The virus infections may be herpes virus infections and HSV-1 or HSV-2 infections in particular.