COMBINATORIAL SYNTHESIS OF LIBRARIES OF MACROCYCLIC COMPOUNDS USEFUL IN DRUG DISCOVERY

摘要

A library of macrocyclic compounds of formula (I), where part (A) is formula (II) bivalent radical, a -(CH2)y- bivalent radical or a covalent bond; where part (B) is formula (III) bivalent radical, a -(CH2)z- bivalent radical, or a covalent bond; where part (C) is formula (IV) bivalent radical, a -(CH2)t- bivalent radical, or a covalent bond; and where part (T) is a - Y - L - Z - radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for their preparation of these compounds in a combinatorial manner, is also disclosed.