Method of producing an optically active beta-hydroxy sulfonic acid compound by catalytic asymmetric hydrogenation

摘要

Disclosed is a method of producing an optically active beta-hydroxy sulfonic acid compound comprising hydrogenating a beta-keto sulfonic acid compound represented by formula 1:where R1 represents an alkyl or a phenyl group, which may be substituted, and R2 represents sodium or an alkyl group, in an acidic solvent, in the presence of an asymmetric catalyst comprising a complex of bivalent Ru, having 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl as a ligand, to produce a compound represented by formula 2:where R1 and R2 are as defined above, and * designates an asymmetric carbon atom.