发明名称 |
Methods and compositions for stimulating neurite growth |
摘要 |
The present invention relates to methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compositions comprise a neurotrophic amount of a compound which binds to the FK-506 binding protein (FKBP) and a neurotrophic factor, such as nerve growth factor NGF. The methods comprise treating nerve cells with the above-described compositions or compositions comprising the FKBP binding compound without a neurotrophic factor. The methods of this invention can be used to promote repair of neuronal damage caused by disease or physical trauma.
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申请公布号 |
US6326387(B1) |
申请公布日期 |
2001.12.04 |
申请号 |
US20000616539 |
申请日期 |
2000.07.14 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
ARMISTEAD DAVID M. |
分类号 |
A61K31/197;A61K31/34;A61K31/40;A61K31/401;A61K31/4025;A61K31/4427;A61K31/4439;A61K31/444;A61K31/445;A61K31/4525;A61K31/4535;A61K31/454;A61K31/4545;A61K31/496;A61K31/506;A61K31/52;A61K31/5377;A61K38/18;A61P25/18;(IPC1-7):A61K31/44;A61K31/41;A61K31/425;A61K31/43;A61K31/415 |
主分类号 |
A61K31/197 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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