Tropane derivatives useful in therapy

摘要

The present invention provides compounds of the formula:
wherein R 1 is C 3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C 1-6 alkyl optionally substituted by one or more fluorine atoms, or C 3-6 cycloalkylmethyl optionally ring-substituted by one or more fluorine atoms; and
R 2 is phenyl optionally substituted by one or more fluorine atoms,
and pharmaceutically acceptable salts and solvates thereof; in combination with one or more additional therapeutic agents.