发明名称 Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands
摘要 The present invention relates to diazabicyclic compounds, preferably to N-aryl diazabicyclic compounds. Of particular interest are 2-pyridinyl diazabicyclic compounds, such as (1S,4S)-2-(5-(3-methoxyphenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane. Other exemplary compounds of the present invention include (1S,4S)-2-(5-(4-methoxyphenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane, (1S,4S)-2-(5-(3-thienyl)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane, (1S,4S)-2-(5-(4-fluorophenoxy)-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane, and (1S,4S)-2-(5-benzoyl-3-pyridyl)-2,5-diazabicyclo[2.2.1]heptane. The present invention also relates to prodrug derivatives of the compounds of the present invention.
申请公布号 AU7495201(A) 申请公布日期 2001.12.03
申请号 AU20010074952 申请日期 2001.05.24
申请人 TARGACEPT, INC. 发明人 CRAIG HARRISON MILLER;GARY MAURICE DULL;LAN MIAO;DWO LYNM;JEFFREY DANIEL SCHMITT;THOMAS JEFFREY CLARK
分类号 A61K31/407;A61K31/439;A61P25/00;A61P25/26;A61P43/00;C07D471/08;C07D487/08 主分类号 A61K31/407
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