| 发明名称 |
Selective epoxidation process for preparing pharmaceutical compounds comprising Cryptophycin 52 |
| 摘要 |
A synthetic method for preparing cryptophycin wherein a compound of Formula (4) may be stereoselectively epoxidised to form a b-epoxide of Formula (I) using a chiral ketone of Formula (7) with an oxidant, such as ozone in the presence of a suitable base such as NaHCO3. |
| 申请公布号 |
NZ336918(A) |
申请公布日期 |
2001.11.30 |
| 申请号 |
NZ19980336918 |
申请日期 |
1998.02.25 |
| 申请人 |
ELI LILLY AND COMPANY;UNIVERSITY OF HAWAII;WAYNE STATE UNIVERSITY |
发明人 |
HOARD, DAVID W;MOHER, ERIC D;NORMAN, BRYAN H;PATEL, VINOD F |
| 分类号 |
C07D303/16;A61K31/395;A61P35/00;C07C229/08;C07C271/22;C07D233/54;C07D277/30;C07D301/03;C07D303/38;C07D303/40;C07D303/46;C07D405/06;C07D405/12;C07D413/06;C07F7/18;(IPC1-7):C07D333/52;C07D209/02;C07D405/02;C07D405/14;C07D303/36;C07D291/00;C07F7/02;C07D317/46;C07D409/02;C07D409/00;C07D303/12;C07D303/08;C07D307/34;C07D233/32;C07D333/72;C07D303/02 |
主分类号 |
C07D303/16 |
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