发明名称 |
NOVEL 4-(3-BENZOFURANYL)PIPERIDINYL AND 4-(3-BENZOTHIENYL)PIPERIDINYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
摘要 |
<p>The invention is concerned with novel compounds of the formulathe pharmaceutically acceptable acid addition salts thereof and the stereochemically isomeric forms thereof, whereinX is oxygen or sulphur; R1 is hydrogen or halo; R2 is hydrogen, C1-4alkyl, phenylmethyl or halophenylmethyl; Alk is C1-4alkanediyl; -Z-A- is a bivalent radical selected from the group consisting of -S-CH2-CH2, -S-CH2-CH2-CH2-, -S-CH=CH-, -CH=CH-CH=CH-, -C(=CHR3)-CH2-CH2-CH2-, -CH=CH-O-, -CHR4-CH2-CH2-, -CHR4-CH2-CH2-CH2-, -CHR4-CH2-CH2-CH2-CH2-; in said bivalent radicals one hydrogen may be replaced by C1-4alkyl; R3 is phenyl or halophenyl; each R4 independently represents hydrogen, hydroxy, phenylmethyl or halophenylmethyl. Pharmaceutical compositions of said compounds and use as a medicine.</p> |
申请公布号 |
GR3036445(T3) |
申请公布日期 |
2001.11.30 |
申请号 |
GR20010401295T |
申请日期 |
2001.08.27 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
VANDENBERK, JAN;KENNIS, LUDO, EDMOND, JOSEPHINE;VAN HEERTUM, ALBERTUS, HENRICUS, MARIA, THERESIA |
分类号 |
A61K31/505;A61K31/517;A61K31/519;A61K31/54;A61P43/00;C07D471/04;C07D498/04;C07D513/04;(IPC1-7):C07D471/04 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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