<p>The invention describes peptides derived from tumor rejection antigen precursor MAGE-2. These peptides bind with HLA-A2 molecules, thus presenting complexes which provoke cytolytic T cell production. The resulting "CTLs" are specific for complexes of HLA-A2 and the peptide. The complexes can be used to generate monoclonal antibodies. The cytolytic T cells produced may be used in the context of immunotherapy, such as adoptive transfer.</p>
申请公布号
GR3036320(T3)
申请公布日期
2001.11.30
申请号
GR20010401171T
申请日期
2001.08.03
申请人
LUDWIG INSTITUTE FOR CANCER RESEARCH;RIJKSUNIVERSITEIT LEIDEN
发明人
MELIEF, CORNELIS, J., M.;VISSEREN, M., W.;KAST, W., M.;VAN DER BRUGGEN, PIERRE;BOON-FALLEUR, THIERRY