SUBSTITUTED AMIDAZO[1,2A]AZINES AS SELECTIVE INHIBITORS OF COX-2

摘要

The present invention relates to new products of formula where in A and B are selected among N and CH, with the condition that when A is N, B is N; R1 is selected amongst CH3 and NH2; R2 and R3 are selected amongst H, CH3, Br, Cl, COOCH3 and OCH3; R4, R5, R6, which are similar or different, are selected in the group comprising of H, F, Cl, Br, (C1-C3)-alkyl, trifluoromethyl, (C1-C3)- alkoxyl and trifluoromethoxyl. The products of said formula are prepared by condensation between a substituted aminoazine and a substituted 2-bromo-2-(4-R1-sulfonylphenyl)-1-phenyltanone in a polar solvant. These new compounds have an activity which inhibits COX-2, with high selectivity in relation to COX-1. They are useful for the treatment of inflammation and/or diseases mediated by cyclo-oxigenases, with the additional advantage that they have a reduced ulcerogenic potential. 23 claims