DETECTION ET CARACTERISATION DE L'ACTIVITE DE PROTEINES IMPLIQUEES DANS LA REPARATION DE LESIONS DE L'ADN

摘要

The invention concerns a method for detecting and characterising the activity of proteins(s) involved in DNA repair, comprising the following steps: a) fixing on a solid support (1) a known damaged DNA O comprising a lesion (7); b) subjecting said damaged DNA to the action of a composition containing at least a protein intervening in the repair of said damaged DNA; and c) determining the activity of said protein for repair by measuring the variation in the signal emitted by a marker (5) which fixes itself on or is eliminated from the support during step b).