| 摘要 |
An apparatus, system, and method are provided for reducing interstitial fluid pressure in tissue, particularly in tumors. The apparatus includes an aspiration probe with at least one slit along its body to provide fluid communication between the aspiration probe and the tissue. Suction in the chamber of the aspiration probe generated by a suction source reduces the interstitial fluid pressure. Compared to prior art devices, the geometry of the slit of the aspiration probe is less likely to become blocked. The present invention also includes a cleaning obturator to unclog the slit and a blocking obturator to prevent accumulation of tissue in the aspiration probe chamber when suction is off. The blocking obturator can be made of a number of biocompatible materials, including a material impregnated with a pharmacological agent. In order to enhance delivery of the pharmacological agent or any drug, the present invention also includes a conducting obturator made of an electrically conductive material to serve as an electroporation electrode. In one embodiment, at least a portion of the aspiration probe is made of an electrically conductive material and serves as an electroporation electrode.
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