摘要 |
Compounds according formula (I) <paragraph lvl="0"><in-line-formula>A-G-Z-W </in-line-formula>and pharmaceutically acceptable salts, solvates or hydrates thereof; wherein, A is (C6-C10)aryl, (C6-C10)aryl-SO2, (C6-C10)aryl-CH2-, (C6-C10)arylcarbonyl, (C1-C9)heteroaryl, (C1-C9)heteroaryl-SO2-, (C1-C9)heteroaryl-CH2-; or (C1-C9)heteroarylcarbonyl; G is selected from the group consisting of: where B is (C6-C10)aryl or (C1-C9)heteroaryl, and X is CH2, SO2, or carbonyl; where X is CH2, SO2, or carbonyl; and R1 and R1' are each independently selected from H, CN, (C1-C8)alkyl-, and phenyl(CH2)-, wherein said alkyl and phenyl groups are optionally substituted; and where Z and W are as defined in the present Specificiation; and pharmaceutical compositions and methods useful to increase secretion of growth hormone(GH) from the anterior pituitary of mammals, including on a sustained release basis.
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