发明名称 REAGENTS FOR CELL SELECTION AND METHODS OF USE
摘要 The present invention provides peptide-ligand conjugates containing a peptide, where a free form of the peptide is capable of displacing a second ligand specific for the peptide. The invention also provides a method of selecting a cell. The method includes the steps of contacting a cell population with a peptide-ligand conjugate, wherein the conjugate comprises a first ligand specific for a cell in the population conjugated to a peptide capable of displacing a second ligand specific for the peptide, thereby forming a cell-conjugate complex; contacting the peptide-ligand conjugate with the second ligand; and isolating the cell-conjugate complex. The method can further include the step of adding a free form of the peptide to release the cell from the complex. The invention also provides a subpopulation of cells containing two or more specifically isolated cells and methods of isolating cell subpopulations. The invention additionally provides a method of diagnosing a condition using peptide-ligand conjugates. The invention further provides a kit for isolating a cell containing a peptide capable of displacing an antibody specific for the peptide and the antibody.
申请公布号 WO0190153(A2) 申请公布日期 2001.11.29
申请号 WO2001US16840 申请日期 2001.05.23
申请人 NEXELL THERAPEUTICS, INC.;SCHAEFFER, ANDREW, T.;TSENG-LAW, JANET;THORNTON, JEFFREY, R.;VAN EPPS, DENNIS, E. 发明人 SCHAEFFER, ANDREW, T.;TSENG-LAW, JANET;THORNTON, JEFFREY, R.;VAN EPPS, DENNIS, E.
分类号 G01N33/53;A61K35/12;A61K47/48;A61P35/00;A61P37/04;A61P37/06;C07K7/06;C07K7/08;C07K16/28;C07K16/30;C07K19/00;C12N5/06;C12N5/08;C12Q1/02 主分类号 G01N33/53
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