摘要 |
An apparatus and method for blood oxygenation is provided, comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vertical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient a catheter, or other interventional fluid delivery device. Alternatively, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator. |
申请人 |
THEROX, INC.;DIVINO, VINCENT, JR.;PATTERSON, WILLIAM, R.;CREECH, JEFFREY, L.;MYRICK, STEPHEN, E.;BUHR, MARK, S.;BENEDICT, JAMES, E., IV;ZAKESKY, PAUL, J. |
发明人 |
DIVINO, VINCENT, JR.;PATTERSON, WILLIAM, R.;CREECH, JEFFREY, L.;MYRICK, STEPHEN, E.;BUHR, MARK, S.;BENEDICT, JAMES, E., IV;ZAKESKY, PAUL, J. |