摘要 |
The present invention provides methods which use 4-amino-azepan-3-one protease inhibitors of cathepsin S in the treatment of diseases in which cathepsin S is implicated, especially treatment or prevention of autoimmune disease; treatment or prevention of a disease state caused by the formation of atherosclerotic lesions and complications arising therefrom; and diseases requiring inhibition, for therapy, of a class II MHC-restricted immune response, inhibition of an asthmatic response, inhibition of an allergic response, inhibition of immune response against a transplanted organ or tissue, or inhibition of elastase activity in atheroma, and novel compounds for use therewith. |
申请人 |
SMITHKLINE BEECHAM CORPORATION;CUMMINGS, MAXWELL, D.;MARQUIS, ROBERT, W., JR.;RU, YU;THOMPSON, SCOTT, K.;VEBER, DANIEL, F.;YAMASHITA, DENNIS, S. |
发明人 |
CUMMINGS, MAXWELL, D.;MARQUIS, ROBERT, W., JR.;RU, YU;THOMPSON, SCOTT, K.;VEBER, DANIEL, F.;YAMASHITA, DENNIS, S. |