THIOUREA DERIVATIVES OF DIHYDROPYRIDINE NPY ANTAGONISTS

摘要

A series of antagonists of NPY have been synthesized and are comprised of thiourea linked piperazine and piperidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula I: where Z is NR<7>R<8> or (i) and X is CH or N. As antagonists of NPY-induced behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.