发明名称 |
YEAST STRAINS TO IDENTIFY SPECIFIC INHIBITORS OF POLO KINASES |
摘要 |
The disclosure provides, in certain embodiments, yeast strains that over-express a polo-box domain from Cdc5 or Plk and thereby exhibit a cytokinesis-defective, chaining growth pattern. These strains, and equivalent cell lines from other species, can be used to identify compounds that modulate polo-like kinase activity. Also described are methods of using polo-box related peptides, and polo-like kinase activity modulatory compounds, to inhibit or enhance cellular proliferation. These peptides and compounds can, for instance, be used to treat a hyper-proliferative disease, disorder or condition, such as neoplasm, through inhibition of polo kinase(s). |
申请公布号 |
WO0190401(A2) |
申请公布日期 |
2001.11.29 |
申请号 |
WO2001US16903 |
申请日期 |
2001.05.23 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;LEE, KYUNG, S.;SONG, SUKGIL;ERIKSON, RAYMOND |
发明人 |
LEE, KYUNG, S.;SONG, SUKGIL;ERIKSON, RAYMOND |
分类号 |
A61P35/00;C12Q1/02 |
主分类号 |
A61P35/00 |
代理机构 |
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