CASPASE INHIBITORS AND USES THEREOF

摘要

This invention provides caspase inhibitors having the formula: (I) wherein Ring A is an optionally substituted piperidine, tetrahydroquinoline or tetrahydroisoquinoline ring; R1 is hydrogen, CHN2, R, or -CH2Y; R is an optionally substituted group selected from an aliphatic group, an aryl group , an aralkyl group, a heterocyclic group, or an heterocyclylalkyl group; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; Ar is an optionally substituted aryl group; and R3 is hydrogen, an optionally substituted C1-6 alkyl, F2, CN, aryl or R3 is attach ed to Ar to form an unsaturated or partially saturated five or six membered fus ed ring having 0-2 heteroatoms. The compounds are useful for treating caspase- mediated diseases in mammals.