发明名称 |
PHARMACEUTICAL COMBINATION OF BICALUTAMIDE AND TAMOXIFEN FOR PROVIDING AN ANTI-ANDROGENIC EFFECT AND AN ANTI-OESTROGENIC EFFECT |
摘要 |
The present invention relates to a pharmaceutical product, daily dose or dose regimen comprising 4'-cyano-<i> alpha '</i>, alpha ', alpha '-trifluoro-3-(4-fluorophenylsulphonyl)-2-hydroxy-2-methylpropriono-<i>m</i>-toluidide (compound I) and tamoxifen. The product comprises compound I and tamoxifen in a ratio of 25 to 350:0.5 to 100 respectively. The invention also relates to a method of providing an anti-antrogenic effect and an anti-oestrogenic effect in a patient, wherein the anti-oestrogenic effects is provided substantially without causing an additional increase in the levels of circulating androgens.
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申请公布号 |
WO0189515(A1) |
申请公布日期 |
2001.11.29 |
申请号 |
WO2001SE01162 |
申请日期 |
2001.05.22 |
申请人 |
ASTRAZENECA AB;FURR, BARRINGTON |
发明人 |
FURR, BARRINGTON |
分类号 |
A61P1/08;A61K31/138;A61K31/165;A61K31/277;A61P1/12;A61P5/28;A61P5/32;A61P15/08;A61P15/10;A61P15/14;A61P29/00;A61P35/00;A61P43/00;(IPC1-7):A61K31/277 |
主分类号 |
A61P1/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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