发明名称 |
-(PYRROLIDIN-1-YLMETHYL)-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE AS MODULATORS OF PROTEIN KINASES |
摘要 |
The present invention is directed to 1-pyrrolidin-1-ylmethyl-3-(pyrrol-2- ylmethylidene)-2-indolinone derivatives of the formula that modulate the activity of protein kinases ("PKs"). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activit y utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
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申请公布号 |
CA2409367(A1) |
申请公布日期 |
2001.11.29 |
申请号 |
CA20012409367 |
申请日期 |
2001.05.24 |
申请人 |
PHARMACIA & UPJOHN COMPANY |
发明人 |
MOON, MALCOLM WILSON;GAO, PING;MOROZOWICH, WALTER |
分类号 |
C07D401/06;A61K31/404;A61K31/4045;A61K31/4439;A61K31/496;A61K31/661;A61P1/00;A61P1/16;A61P3/00;A61P3/10;A61P7/02;A61P9/00;A61P9/08;A61P9/10;A61P11/00;A61P13/12;A61P17/00;A61P17/02;A61P17/06;A61P19/02;A61P19/04;A61P25/00;A61P25/28;A61P29/00;A61P31/00;A61P31/04;A61P35/00;A61P37/00;A61P37/06;A61P43/00;C07D401/14;C07D403/06;C07D403/14;C07F9/572;C07F9/6558;(IPC1-7):C07D403/06 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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