MACROCYCLIC HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS ANTIMICROBIAL AGENTS

摘要

The invention concerns macrocyclic hydroxamic acid derivatives of general formula (I) wherein: Y is -CH2-, -CH2-CH2- or -CH=CH- and Z and Z' represent -CH2- or Y-Z or Y-Z' represent -CH=CH- and Z and Z' are defined as above; X is -CH2, O, or S; R1 is non-substituted or substituted phenyl or cycloalkyl (5 to 6 members), monocyclic or bicyclic heterocyclyl (5 to 10 members), saturated or unsaturated (1 to 3 heteroatoms: N, O or S), optionally substituted or N-oxidized, or alkyl optionally substituted; R2 is H, alkyl or hydroxyalkyl optionally substituted; R3 is H, alkyl, alkyloxycarbonyl, carbamoyl, alkylcarbamoyl or dialkylcarbamoyl, or R2 and R3 form with the atoms to which they are bound, a nitrogenous heterocycle with 5 to 6 members capable of further containing another heteroatom selected among N, O or S, and optionally substituted, with an alkyl radical, hydroxyalkyl or OH; R4 and R'4, identical or different, represent H, OH, alkyl, hydroxyalkyl or alkyloxy; the C1-C4 alkyl or acyl radicals are linear or branched; and their salts when they exist and when R4 and R'4 are different, their diastereoisomeric forms. The derivatives of general formula (I) are particularly useful as antimicrobial agents.