Method and composition for deforming soft tissues

摘要

The present invention provides a composition and method for augmenting soft tissue, which composition includes a continuous phase that is a solid at temperatures less than about 10 DEG C or greater than about 30 DEG C and is a fluid at temperatures between about 10 DEG C and about 30 DEG C, and which contains an aqueous solvent having dissolved therein a hydrogel and a dehydrating agent, and a discontinuous phase containing a plurality of hydrophilic hydrogel particles that are swellable in the aqueous solvent, that are not biodegradable for periods of time in excess of one year, and that have a hydrated diameter of greater than about 25 microns upon hydration by physiologic fluid; wherein the final volume of the hydrophilic hydrogel particles upon hydration by physiologic fluid is substantially the same as the initial volume of the composition used to augment the soft tissue.