发明名称 |
Cyclic amino acid derivatives useful as pharmaceutical agents |
摘要 |
<p>Pro-drug compounds of the formula (I) or (II) are provided that when administered to humans or other mammals provide an increased duration of active compound in the plasma compared to compounds of corresponding structure in which labile groups are not present. <EMI ID=1.1 HE=46 WI=100 LX=613 LY=1101 TI=CF> In the above formulae:<BR> ```n is 0, 1 or 2;<BR> ```P represents hydrogen or methyl;<BR> ```Q represents a labile amine- or amide-forming organic group that becomes removed in the human or animal body, and in a compound of formula (I) is other than acyl;<BR> ```R<SP>1</SP> represents hydrogen or a labile ester-forming group selected from substituted and unsubstituted C<SB>1</SB> - C<SB>6</SB> alkyl, benzyl and phenyl groups that become removed in the human or animal body;<BR> ```R<SP>2</SP> represents methyl; and<BR> ```the groups R<SP>3</SP> (which when n is 2 may be the same or different) represent a C<SB>1</SB> - C<SB>6</SB> alkyl. The compounds may be used to treat a range of neurological conditions, e.g. epilepsy or pain.</p> |
申请公布号 |
GB2362646(A) |
申请公布日期 |
2001.11.28 |
申请号 |
GB20000012850 |
申请日期 |
2000.05.26 |
申请人 |
* WARNER-LAMBERT COMPANY |
发明人 |
JUSTIN STEPHEN * BRYANS;DAVID CLIVE * BLACKEMORE;SOPHIE CAROLINE * WILLIAMS |
分类号 |
A61P1/04;A61K31/16;A61K31/195;A61K31/216;A61K31/222;A61K31/235;A61K31/27;A61P25/00;A61P25/04;A61P25/08;A61P25/22;A61P25/24;A61P25/28;C07C205/43;C07C233/47;C07C233/51;C07C233/84;C07C235/42;C07C271/22;(IPC1-7):C07C233/47;C07C235/46 |
主分类号 |
A61P1/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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