发明名称 |
DETECTION OF ANTI-HEPATITIS B DRUG RESISTANCE |
摘要 |
The present invention relates to a method for the monitoring of anti-HBV drug resistance in a patient by genetic detection of at least one of the mutations L528M, M552V/I and/or V/L/M555I in the DNA polymerase of the HBV strains present in a biological sample of said patient. The present invention provides new HBV DNA polymerase sequences to be used for the design of new probes allowing a very specific and sensitive detection of anti-HBV drug resistance. |
申请公布号 |
EP1144693(A3) |
申请公布日期 |
2001.11.28 |
申请号 |
EP20000951337 |
申请日期 |
2000.07.05 |
申请人 |
INNOGENETICS N.V. |
发明人 |
STUYVER, LIEVEN;MAERTENS, GEERT;VAN GEYT, CAROLINE |
分类号 |
C12N15/09;C12Q;C12Q1/68;C12Q1/70 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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