METHOD FOR DETECTING MALIGNANT DISEASES

摘要

PCT No. PCT/SE90/02314 Sec. 371 Date Jul. 23, 1991 Sec. 102(e) Date Jul. 23, 1991 PCT Filed Dec. 27, 1990 PCT Pub. No. WO91/10139 PCT Pub. Date Jul. 11, 1991.In order to aid in the detection of malignant diseases the sample of a body fluid is incubated with at least two receptors R1 and R2 in which a signal change is produced by binding of at least the receptors R1 and R2 to the substance to be detected in the sample solution and in which one of the two receptors contains a monoclonal antibody which binds to the amino acid sequence 311 to 335 of cytokeratin 19 and the other receptor contains a monoclonal antibody which binds to the amino acid sequence 346 to 359 of cytokeratin 19 and the signal change in the sample caused by the binding is determined.