发明名称 |
DNA encoding kainate-binding, human CNS receptors of the EAA5 family |
摘要 |
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors of the kainate-binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.
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申请公布号 |
US6322999(B1) |
申请公布日期 |
2001.11.27 |
申请号 |
US19950377503 |
申请日期 |
1995.01.24 |
申请人 |
NPS ALLELIX CORP. |
发明人 |
KAMBOJ RAJENDER;ELLIOTT CANDACE E.;NUTT STEPHEN L. |
分类号 |
A61K38/00;A61K39/395;A61P25/00;C07K14/00;C07K14/705;C07K16/00;C12N5/10;C12N15/09;C12P21/02;C12P21/08;C12R1/91;F02B75/02;G01N33/53;G01N33/566;(IPC1-7):C12P21/06;C12P21/04;C07H21/02;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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