发明名称 |
Sterol-regulated Site-1 protease and assays of modulators thereof |
摘要 |
The invention provides assays for the identification of modulators of Site-1 protease. Further provided by the invention are expression constructs and the transgenic cells useful for the development of such assays for Site-1 specific protease. The cells allow the implementation of in vitro assays for potential modulators of Site-specific proteases. Still further provided by the invention are in vitro assays employing Site-1 protease which has been isolated from cells.
|
申请公布号 |
US6322962(B1) |
申请公布日期 |
2001.11.27 |
申请号 |
US19990360237 |
申请日期 |
1999.07.23 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
BROWN MICHAEL S.;CHENG DONG;ESPENSHADE PETER J.;GOLDSTEIN JOSEPH L.;RAWSON ROBERT B.;SAKAI JURO |
分类号 |
C12N9/64;(IPC1-7):C12Q1/00;C12Q1/68;C12N15/00;C12N15/09;C12N15/63 |
主分类号 |
C12N9/64 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|