HETEROCYCLIC COMPOUND HAVING ANGIOTENSIN II ANTAGONISM

摘要

PROBLEM TO BE SOLVED: To provide a heterocyclic compound having potent angiotensin II antagonism, therefore useful as a therapeutic agent for hypertension or the like. SOLUTION: This heterocyclic compound is shown by formula I [R1 is a hydrocarbon residue which may be bound via a heteroatom and substituted; R2 is an anion-forming group or a group convertible to an anion; R3 is a (substituted) aromatic hydrocarbon residue or (substituted) heterocyclic group containing a heteroatom; X indicates that R3 and W are bound to each other either directly or via a spacer with <=2 atomic chains; W is a (substituted) aromatic hydrocarbon residue or (substituted) heterocyclic group containing a heteroatom; (a), c and d are each 1 or 2 (substituted) carbon atom(s) or heteroatom(s); b and e are each a (substituted) carbon atom; the broken line indicates that one double bond exists; n is 1-2; and when (a) is a (substituted) carbon atom, R1 and (a) are bound to each other to form a group of formula II which may be a ring].