发明名称 |
Cancer treatments by using a combination of an antibody against her2 and interleukin -2 |
摘要 |
Methods for treating a subject with a cancer that is characterized by overexpression of HER2 receptor protein using a combination of interleukin-2 (IL-2) or variant thereof and at least one anti-HER2 antibody or fragment thereof are provided. These anti-tumor agents are administered as two separate pharmaceutical compositions, one containing IL-2 (or variant thereof), the other containing at least one anti-HER2 antibody (or fragment thereof), according to a dosing regimen. Administering of these two agents together potentiates the effectiveness of the anti-HER2 antibody alone, resulting in a positive therapeutic response that is improved with respect to that observed with this anti-tumor agent. |
申请公布号 |
AU6156901(A) |
申请公布日期 |
2001.11.26 |
申请号 |
AU20010061569 |
申请日期 |
2001.05.15 |
申请人 |
HEALTH RESEARCH INC.;ARCH DEVELOPMENT CORPORATION |
发明人 |
MICHAEL A. CALIGIURI;NEAL J. MEROPOL;RICHARD L. SCHILSKY |
分类号 |
A61K9/19;A61K38/00;A61K39/395;A61P35/00;A61P43/00;C07K16/32 |
主分类号 |
A61K9/19 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|