发明名称 |
MODULATION OF INFLAMMATION BY PROTEASE PRODUCTS |
摘要 |
The invention provides methods of inhibiting the biological activity or the in vivo biological activity of CC-chemokines (including native MCP-3), such as methods of inhibiting inflammation, comprising administering to a host an effective amount of a CC-chemokine receptor antagonist of the present invention. In same embodiments, the invention may provide methods of modulating an immune response in a host, or treating inflammation or autoimmune disease in a host suffering from such diseases, comprising administering to the host an effective amount of a CC-chemokine receptor antagonist of the present invention. Another aspect of the present invention is directed to pharmaceutical compositions comprising an antagonistically effective amount of a CC-chemoki ne receptor antagonist of the present invention and a pharmaceutically ecceptab le carrier. In alternative aspects, the invention provides compounds and method s for cancer treatment that facilitate an affective immune response.
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申请公布号 |
CA2316405(A1) |
申请公布日期 |
2001.11.26 |
申请号 |
CA20002316405 |
申请日期 |
2000.08.17 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
GONG, JIANG-HONG;MCQUIBBAN, G. ANGUS;CLARK-LEWIS, IAN;OVERALL, CHRISTOPHER MARK |
分类号 |
A61K38/00;A61P29/00;A61P35/00;A61P37/06;C07K14/52;C12N15/19;(IPC1-7):C07K14/52;A61K38/19;A61P31/00 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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